The Middle East Peace Initiative includes a wide range of interreligious encounters, fact-finding trips, interfaith dialogues, cultural initiatives, athletic programs, and service-learning projects.

Interreligious encounters: MEPI is distinctive in that Jews, Christians, and Muslims travel together to each others’ holy sites and gain a mutual and first-hand understanding of the history and traditions of the Abrahamic faiths. For many participants, this is the first substantial encounter with the people and traditions of the other faiths in a religious context. During such shared experiences, people enrich one another with their unique perspectives. This helps strengthen one's own faith and dissolve barriers of ignorance, distrust, and fear. Interfaith dialogues offer fresh insights into some commonalities among the religions rooted in this part of the world.

Interfaith service-learning, cultural, and athletic programs offer personal contact and build understanding and respect among people of different communities.

Inclusion of interreligious perspectives in policy discussions: Middle East peace talks generally do not involve spiritual leaders or address religious issues. Interfaith leaders in MEPI have held briefings with members of the Israeli Knesset, Palestinian authorities, and leaders in Jordan and Lebanon to advocate for closer involvement with faith communities.

Members of Parliament from many nations have attended MEPI briefings and spoken about how they apply the wisdom of their religious traditions to the issues before them in their own countries, leading to animated discussions about applicability in the Middle East.